Clinical Implications of Biofilm Formation by ed UTI. Our study indica in the Urinary Tract
نویسندگان
چکیده
The potential relationships between biofilm formation and pathogenicity of in urinary tract infections(UTI)were investigated. Over a 12-year period from 1991 through 2002, a total of 352 isolates were collected from patients with complicated UTI(one isolate per patient) at the urology ward of Okayama University Hospital. We analyzed the prevalence and transferability of genes encoding virulence factors( / )and antimicrobial resistance( / ). The production of biofilm, hemolysin and gelatinase by these isolates was also examined and the associated medical records of patients were retrospectively reviewed. Of 352 isolates, 315 possessed and/or genes. Of the 63 hemolysin-and 167 gelatinase-producing isolates, 59 and 94 isolates, respectively, possessed both and genes. isolates with both and genes formed biofilms at significantly higher rates than those with neither gene( =0.038). The genes encoding , and / were transferable and appeared to have accumulated in these isolates. The isolates possessing and/or genes were found from both catheter-related or -unrelat
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